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About 5% to 10% of breast cancers are thought to be hereditary, caused by abnormal genes passed from parent to child.

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The study followed 24 postmenopausal women diagnosed with breast cancer at least five years previously, all of whom were free of recurrences, and had completed all breast cancer treatment (including any aromatase inhibitors or tamoxifen) at least three months prior to enrolling in the trial.

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This puzzling result, along with the weak association and multiple statistical comparisons made for many different trial endpoints, diminishes the strength of evidence provided by the PHS II trial.

There are also differences in approaches between the United States and other countries in terms of the treatments used.

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The base population encompassed 10 011 women with a first-time diagnosis of breast cancer in or after 1980.

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