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An ECOG study has shown that addition of the anti-angiogenesis agent bevacizumab (Avastin) to standard first-line carboplatin-paclitaxel resulted in significant prolongation of survival.

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Treatment continued until progression of the disease, development of unacceptable toxic effects, a request by the patient or physician to discontinue treatment, serious noncompliance with the protocol, or completion of six chemotherapy cycles.

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This new drug can be used in adult patients who have a specific mutation in their cancer cells that can lead to faster tumor growth.

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Effects of Src inhibitors on cell growth and epidermal growth factor receptor and MET signaling in gefitinib-resistant non-small cell lung cancer cells with acquired MET amplification.

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Inamura K, Takeuchi K, Togashi Y, Hatano S, Ninomiya H, Motoi N, et al.

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It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to imatinib.

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También se agregó que de manera similar al análisis de la SSA, la SG se estratificó según el tipo de mutación en EGFR y el origen étnico.

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Both are small molecule orally-bioavailable tyrosine kinase inhibitors (TKIs) of the EGFR TK domain, and have been shown to improve survival compared to placebo in asian patients when administered after failure of first or second line chemotherapy for advanced NSCLC.

Role of race in oncogenic driver prevalence and outcomes in lung adenocarcinoma: Results from the Lung Cancer Mutation Consortium.

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While this analysis has the obvious limitations of a retrospective study, we feel that the risk of disease flare in this patient population is significant enough to merit modification of clinical trial design to abbreviate standard washout periods in trials for patients with EGFR-mutant lung cancer and acquired resistance.

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